Among the most notable is John Ritter, the charming Jack Tripper, whose unexpected death in 2003 at just 54 left fans devastated. Ritter, known for his impeccable comedic timing, suffered a tragic aortic dissection that abruptly ended his vibrant career. Similarly, the iconic Don Knotts, who portrayed Ralph Furley, battled personal demons throughout his life before passing away in 2006 at the age of 81, leaving behind a legacy marred by anxiety and health struggles.